{"id":750,"date":"2006-12-12T14:25:34","date_gmt":"2006-12-12T18:25:34","guid":{"rendered":"http:\/\/www.chrismclaren.com\/blog\/archives\/2006\/12\/12\/this-is-my-good-friend\/"},"modified":"2006-12-12T14:25:34","modified_gmt":"2006-12-12T18:25:34","slug":"this-is-my-good-friend","status":"publish","type":"post","link":"http:\/\/www.chrismclaren.com\/blog\/2006\/12\/12\/this-is-my-good-friend\/","title":{"rendered":"This is my good friend"},"content":{"rendered":"<p><a href=\"http:\/\/en.wikipedia.org\/wiki\/Ibuprofen\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.chrismclaren.com\/blog\/wp-content\/images\/2006\/12\/Ibuprofen3Dl.png\" width=\"400\" height=\"270\" alt=\"Ibuprofen 3d Model\" title=\"Ibuprofen 3d Model\" class=\"aligncenter\"\/><\/a><\/p>\n<p>That&#8217;s a <a href=\"http:\/\/en.wikipedia.org\/wiki\/NSAID\">non-steroidal anti-inflammatory drug<\/a> believed to work through inhibition of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Cyclooxygenase\">cyclooxygenase<\/a> (COX), thus inhibiting <a href=\"http:\/\/en.wikipedia.org\/wiki\/Prostaglandin\">prostaglandin<\/a> synthesis. There are at least 2 variations of cyclooxygenase (COX-1 and COX-2), and this inhibits both COX-1 and COX-2. It appears that its analgesic, antipyretic, and anti-inflammatory activity are achieved principally through COX-2 inhibition; whereas COX-1 inhibition is responsible for its unwanted effects on platelet aggregation and the GI mucosa.<\/p>\n<p>Yes, I understand what all of that means, at least at a &#8220;dinner-party conversation&#8221; level.<\/p>\n<p>No, I do not have a &#8220;Trust me, I&#8217;m a doctor&#8221; t-shirt.<\/p>\n<p>And no, even if I did have the shirt, I probably couldn&#8217;t pull it off.<\/p>\n","protected":false},"excerpt":{"rendered":"<p class=\"excerpt\">That&#8217;s a non-steroidal anti-inflammatory drug believed to work through inhibition of cyclooxygenase (COX), thus inhibiting prostaglandin synthesis. There are at least 2 variations of cyclooxygenase (COX-1 and COX-2), and this inhibits both COX-1 and COX-2. It appears that its analgesic, antipyretic, and anti-inflammatory activity are achieved principally through COX-2 inhibition; whereas COX-1 inhibition is responsible for its unwanted effects on&hellip; <a href=\"http:\/\/www.chrismclaren.com\/blog\/2006\/12\/12\/this-is-my-good-friend\/\">Read more &rarr;<\/a><\/p>\n","protected":false},"author":13,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[3],"tags":[],"class_list":["post-750","post","type-post","status-publish","format-standard","hentry","category-technology","xfolkentry"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5UQvw-c6","_links":{"self":[{"href":"http:\/\/www.chrismclaren.com\/blog\/wp-json\/wp\/v2\/posts\/750","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.chrismclaren.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.chrismclaren.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.chrismclaren.com\/blog\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"http:\/\/www.chrismclaren.com\/blog\/wp-json\/wp\/v2\/comments?post=750"}],"version-history":[{"count":0,"href":"http:\/\/www.chrismclaren.com\/blog\/wp-json\/wp\/v2\/posts\/750\/revisions"}],"wp:attachment":[{"href":"http:\/\/www.chrismclaren.com\/blog\/wp-json\/wp\/v2\/media?parent=750"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.chrismclaren.com\/blog\/wp-json\/wp\/v2\/categories?post=750"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.chrismclaren.com\/blog\/wp-json\/wp\/v2\/tags?post=750"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}